Roles of the kinase TAK1 in TRAF6-dependent signaling by CD40 and its oncogenic viral mimic, LMP1.
The Epstein-Barr virus (EBV)-encoded protein latent membrane protein 1 (LMP1) is essential for EBV-mediated B cell transformation and plays a critical role in the development of post-transplant B cell lymphomas.LMP1 also contributes to the exacerbation of autoimmune diseases such as systemic lupus erythematosus (SLE).LMP1 is a functional mimic of t